In this episode of The Ready Room I speak with Dr. Matthew Johnson. Matt is a Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University, and an expert on the behavioral and psychological effects of psychoactive drugs in humans. Matt talks about how one finds his way into making a (legal and respectable) living on magic mushrooms. We shine a light on the little-known connection between LSD and “I Dream of Jeannie”. We discuss whether Charles Dickens’ transformative tale of redemption can be replicated in reality. We talk about the positive benefits of psilocybin for those suffering from addiction, depression, and anxiety, and what science has been able to tell us about how our brains are wired and possibly re-wired.